Skip to Main Content

Literature Reviews: Systematic reviews

Why doing a systematic review?

"The core of evidence synthesis is the systematic review of literature of a particular intervention, condition or issue.

The systematic review is essentially an analysis of the available literature (that is, evidence) and a judgment of the effectiveness or otherwise of a practice [...]"

JBI, 2020.

 

illustration of the hierarchy of evidence. A pyramid with systematic reviews at the top, as they are the strongest methodology in healthcare research, if applied correctly.

Systematic reviews gather, appraise and synthesise data from all available research to answer a focused research questions. These reviews are conducted to:

  • Find an answer when different studies have (slightly) different conclusions. 
  • Minimise risk of bias and influence of errors
  • Inform best practice, guidelines and policies. 

 

Systematic reviews answer a well defined, focused search question and are transparent in their methodology. the sleection of studies is based on pre-defined inclusion and exclusion criteria that are also clealry reported. 

For these reasons, systematic reviews, together with meta-analysis in healthcare sit at the top of the hierarchy of evidence. 

 

The below guidance is meant to be a starting point for you to begin work on your systematic review. 

1. Deciding a topic

photo of books on a shelf

You might be assigned a topic by your supervisor, or you might be able to choose it yourself. Either way, your topic and research question should focus on something that is still uncertain in the wider literature. You might have come across studies with contradicting results, or you might know of a topic that is controversial and or lacking guidance. In other words, the topic has no clear conclusion and the evidence is not sufficient. 

To define a topic or question, you might want to:

  • Search the literature: use big, comprehensive databases to explore what has already been done and any gaps other researchers have identified. You might want to use review filters to sort results.

Possible databases include: Web of Science and Scopus (multi-disciplinary), Proquest (Business and Social Sciences), IEEE Explore (engineering).

  • Search PROSPERO for registered protocols (these are mainly healthcare and public health reviews).
  • Discuss possible topics with your supervisor.

The more you explore the literature, the clearer your chosen topic will be.

You might be ready for step 2: formulating a research question.

3. Choosing databases

photo of a mobile showing an article found on Pubmed, a healthcare database

You will now have a clear idea of what you want to find out, so you need to decide where to find that information. In other words, you need to select databases to search for studies. 

Systematic reviews normally use around 5 databases, but this might vary depending on what the purpose of your review is (is this an assignment?) and the expectations set on you by your supervisor or lecturer.

You might also want to think about other sources beyond bibliographic databases, for example, sources of grey literature, clinical trials registers, conference papers, reports etc. 

Refer to your Subject LibGuide to explore what databases are most relevant to your topic. You want a mix of multi-disciplinary, broad databases and more specialised ones. You might also need to seek advice from your Information Specialist. 

2. Formulating a focused question

photo of a lens focussing on a detail, when the background is blurry

Consider using question frameworks to formulate a well defined, focused research questions. These are acronyms used to identify the main components of the question. Common frameworks are:

PICO: Population, Intervention, Comparison, Outcome

SPIDER: Sample, Phenomenon of Interest, Design, Evaluation, Research Type

CIMO: Context, Intervention, Mechanisms, Outcomes

Here you can find a breakdown of all frameworks, with examples included.

Your question might not fit into a framework; however you want to make sure that it is still clear and focused. The scope of the question should not be too broad. 

You can now move to step 3: selecting databases.

4. Developing your search strategy

screenshot of an advanced search strategies, showing that every detail is reported line by line

After selecting databases, you need to prepare a search strategy. 

1. Think about the main concepts that you need to include in your search (you can refer back to your question framework). These will be the building blocks of your search.

2. For each concept, think of alternative keywords. 

3. Combine groups of keywords with appropriate database operators. 

4. Re-write the strategy for each database, keeping the same keywords but changing symbols and operators as needed.

If this is your first time writing an advanced strategy, you might need to ask your Information Specialist for help. They will also be able to give you feedback on what you have already prepared.

Search strategies will need to be reported in full as part of your appendices.

These 4 general steps are the beginning of your searches and a good starting point for the review. Check further resources below for more information and step-by-step methodology.

Further resources

Need advice?

Your Information Specialist can help you with:

  • Clarifying methodologies
  • Advice on appropriate search strategies
  • Advice on database selection
  • Advice on searching grey literature

Book an online 1-1 appointment here >>>                                                   

photo of a teacher during a session, This links to the appointment booking system.